CNS Cancer
Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches
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Book Description
The volume will cover three areas of research in brain tumors: a) animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; b) Prognostic factors and biomarkers; c) Therapeutic targets and targeting approaches to brain tumors.
Other Subjects
Table of Contents
Chapter 1: PDGF-Based Malignant Glioma Model in Rats and Mice.- Chapter 2: Modeling Brain Tumors Using Avian Retroviral Gene Transfer.- Chapter 3: Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomas.- Chapter 4: Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role p21-Ras in Glioblastoma Multiforme.- Chapter 5: Pten-Deficient Mouse Models for High-Grade Astrocytomas.- Chapter 6: The NF1/p53 Knockout Transgenic Model for Malignant Glioma.- Chapter 7: Conditional Models for Brain Tumors in Transgenic Mice.- Chapter 8: Human Brain Tumor Cell and Tumor Tissue Transplantation Models.- Chapter 9: Transformation of Human Brain Cells in Culture as Models for Brain Tumors.- Chapter 10: History of Important Carcinogen-Induced Brain Tumor Cell Lines.- Chapter 11: Neuro-Oncogenesis Induced by Nitroso-Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition.- Chapter 12: The Murine GL261 Glioma Experimental Model to Assess Novel Brain Tumor Treatments.- Chapter 13: Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems.- Chapter 14: P53 Alterations in Brain Tumors.- Chapter 15: The PTEN/PI3 Kinase Pathway in Human Glioma.- Chapter 16: Value of 1p/19q and Other LOH Markers for Brain Tumor Diagnosis, Prognosis and Therapy.- Chapter 17: Discovery of Genetic Markers for Brain Tumors by Comparative Genomic Hybridization.- Chapter 18: Genomic Identification of Significant Targets in Brain Cancer.- Chapter 19: Oncogenic Pathway Markers.- Chapter 20: Aberrant EGFR Signaling in Glioma.- Chapter 21: Mechanisms of Brain Tumor Angiogenesis.- Chapter 22: Vaso-Occlusive Mechanisms that Intiate Hypoxia and Necrosis in Glioblastoma: The Role of Thrombosis and Tissue Factor.- Chapter 23: Expression Profiling of Glioblastoma Defines Distinct Subtypes.- Chapter 24: Proteomic Profiling of Human Brain Tumors.- Chapter 25: Discovery of Biomarkers in the Cerebrospinal Fluid of Brain Tumor Patients.- Chapter 26: Epigenetic Profiling of Gliomas.- Chapter 27: Micro RNAs in the Central Nervous System and Potential Roles of RNA Interference in Brain Tumors.- Chapter 28: Understanding Glioma Resistance to Temozolomide Therapy.- Chapter 29: Markers of Cancer Stem Cells for Brain Tumor Prognosis.- Chapter 30: Clinical Agents for the Targeting of Brain Tumor Vasculature.- Chapter 31: GBM Neovascularization: Impact of Bone Marrow-Derived Cells and Evasive Mechanisms of Antiangiogenic Therapy.- Chapter 32: Novel Phage and Viral Targeting Vehicles for Brain Tumor Therapy.- Chapter 33: Impact of the Blood Brain Barrier on Brain Tumor Imaging and Therapy.- Chapter 34: Targeting CXCR4 in Brain Tumors.- Chapter 35: Molecular Targeting of IL-13Ra2 and EphA2 Receptor in GBM.- Chapter 36: Brain Tumor Targets for Antibody-Mediated Immuno-Therapy.- Chapter 37: STAT3 Oncogenic Signaling in Brain Tumors.- Chapter 38: Inhibition of Ras Signaling in Brain Tumors.- Chapter 39: HGF/c-Met Signaling and Targeted Therapeutics in Brain Tumors.- Chapter 40: Combinatorial Therapeutic Strategy for Blocking Kinase Pathways in Brain Tumors.- Chapter 41: Targeting of TRAIL Apoptotic Pathways for Glioblastoma Therapies.- Chapter 42: The NF-kB Signaling Pathway in GBMs, Implications for Apoptotic and Inflammatory Responses and Exploitation for Therapy.- Chapter 43: Targeting Endoplasmic Reticulum Stress for Malignant Glioma Therapy.- Chapter 44: Targeting Adult and Pediatric Brain Cancer Stem Cells.- Chapter 45: The Use of Retinoids as Differentiation Agents Against Medulloblastoma.- Chapter 46: Herpes Simplex Virus 1 (HSV-1) for Glioblastoma Multiforme Therapy.- Chapter 47: The Development of Targeted Cancer Gene-Therapy Adenoviruses for High-Grade Glioma Treatment.- Chapter 48: Harnessing T-cell Immunity to Target Brain Tumors.- Chapter 49: Glioma Invasion: Mechanisms and Therapeutic Challenges.-
