From Local Invasion to Metastatic Cancer
Involvement of Distant Sites Through the Lymphovascular System
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Book Description
In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.
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Table of Contents
Introduction Stanley P. L. Leong Part I. Tumor Microenvironment and Proliferation Chapter 1 Dynamic Reciprocity Between Tumor Cells and the Microenvironment - Mina J. Bissell Chapter 2 Inflammation as a Regulator of Epithelial Cancer Development – Lisa Coussens Chapter 3 Targeting Molecular Signals in the Tumor Cell Microenvironment - Richard E.B. Seftor Chapter 4 Convergence of Embryonic and Tumorigenic Pathways: Role in Tumor Progression - Mary J.C. Hendrix Part II. Lymphangiogenesis and Angiogenesis Chapter 5 Heme-Lymph Vasculo/Angiogenesis, Angiotumorigenesis, and Tumor Angiogenesis: A Lymphatic System Perspective – Marlys Witte Chapter 6 Model Systems to Study Lymphangiogenesis and Angiogenesis: Lessons for Tumor Biology – Joerg Wilting Chapter 7 Vascular Permeability Factor, Lymphangiogenesis/Angiogenesis, and Cancer Biology – Harold Dvorak Chapter 8 Molecular Events and Clinical Correlations in Tumor and Other Lymphangiogenesis – David Jackson Chapter 9 Tumor Lymphangiogenesis: What We Know and Don't Know – Jonathan Sleeman Part III. Diagnostic Imaging of Cancer Chapter 10 Molecular Imaging of Cancer - Receptors, Angiogenesis and Gene Expression Heiko Schoder Chapter 11 MRI and Ultrasound Imaging of Lymph Node - Robert Mattrey Chapter 12 Molecular Imaging of the Sentinel Lymph Node - Anne Wallace Chapter 13 Lymphatic Dysfunction and Scintigraphy in Cancer Patients - Edwin Glass Chapter 14 Molecular Imaging of Neuroendocrine Cancer by fusion SPECT/CT - Alain Pecking Chapter 15 Concepts and Tools of Imaging Cancer - Farhard Daghigian Part IV. Therapeutic Targeting of the Lymphovascular System Chapter 16 Therapeutic Targeting of the Lymphovascular System – Jeffrey Gershenwald Chapter 17 Targeted Introduction of Substances into the Lymph Nodes for Endolymphatic Therapy - Peter Hirnle Chapter 18 Targeting Lymphovascular Endothelium with Anti-VEGFR-3 Monoclonal Antibodies - Bronislaw Pytowski Chapter 19 Radioimmunotherapy for Cancer – Andrew Raubitschek Chapter 20 Animal Models to Study Lymphatic and Vascular Metastasis - David Nathanson and Ann Chambers Part V: Molecular Mechanisms of Metastasis Chapter 21 Early Development of Micrometastasis in Tumor-Draining Regional Lymph Nodes: Can They Be Predicted – Dave S. B. Hoon Chapter 22 Micrometastasis in Patients with Solid Epithelial Tumors - Klaus Pantel Chapter 23 Imaging Tumor Metastasis and Dormancy in Experimental Models -Ann Chambers Chapter 24 Chemokine Receptors and Organ-Specific Metastasis - Bernard Homey Chapter 25 Tumor and Lymph Node Lymphangiogenesis: Impact on Metastasis - Michael Detmar Chapter 26 Role of the Tumor Microenvironment on Tumor Cell Survival and Metastasis - David Cheresh Chapter 27 Treg, Chemokines and other Small Molecules: Role in Metastasis and its Prevention - Marty Mihm Chapter 28 Breast Cancer Metastasis to the Brain – Patricia Steeg Chapter 29 Chemokines, Lymphatics and Metastasis – Robert Ferris and Timothy Padera Part VI: Molecular Targeted Therapy Against Growth Factor Receptors, Signaling Pathways and Angiogenesis As Therapeutic Targets Chapter 30 Molecular Targeting of Lymphangiogenesis and Tumor Metastasis - Kari Alitalo Chapter 31 Beyond VEGF: Angiopoietins and Ephrins as Therapeutic Targets – Hellmut Augustin Chapter 32 VEGF Trap in Trials Today, and VelociGene with VelocImmune for the Angiogenesis Targets of Tomorrow - George Yancopoulos Chapter 33 Targeting EGFR/Angiogenesis – Athanassios Argiris Chapter 34 Targeting Signaling Pathways in Cancer Therapy – Harold Wanebo Part VII: Impact of Nodal Status and Tumor Burden in Sentinel Nodes on the Clinical Outcome Chapter 35 Micrometastasis of Melanoma to SLNs - Stanley Leong Chapter 36 Micrometastasis of Breast Cancer to SLNs - Markus Zuber Chapter 37 Micrometastasis of Head and Neck Cancer to SLNs - Jochen Werner Chapter 38 Micrometastasis of Genitounrinary Cancer to SLNs - Ramon Cabanas Chapter 39 Micrometastasis of Colorectal Cancer to SLNs - Sukamal Saha Chapter 40 Micrometastasis of Upper GI Cancer to SLNs - Yuko Kitagawa Chapter 41 Application of Cancer Biology in Cancer Staging and Predicting Clinical Outcome - Frederick Greene Chapter 42 Should Regional Lymph Node Dissection be done for Breast Cancer? Douglas Reintgen and Blake Cady Part VIII: Immune Responses in the Draining Lymph Nodes Against Cancer: Implication for Immunotherapy Chapter 43 Role of Lymph Nodes in Immunotherapy of Malignant Tumors - Suyu Shu Chapter 44 Tumor-Related Immune Modulation of the Regional Lymph Nodes - Alistair Cochran and Rong-Rong Huang Chapter 45 Reversal of Immune Suppression in Sentinel Lymph Nodes - Richard Essner Chapter 46 Immunomodulation of the Sentinel Node and Systemic Immunity in Melanoma - Donald Morton Chapter 47 Vaccine-Primed Lymph Node Cells in the Adoptive Immunotherapy of Cancer - Fred Chang Chapter 48 Laboratory Monitoring of Immune Functions in Immunotherapy Trials – Holden Maeker Chapter 49 Strategies of Developing Cancer Immunotherapies - Karin Jooss Part IX: The Role of Stem Cells in Cancer Metastasis Chapter 50 Stem Cells in Metastatic Melanoma - Ruby Ghadially Chapter 51 Implications of Cancer Stem Cells for Metastasis - Michael Clarke Chapter 52 Prostate Cancer Stem Cells: Identification, Characterization, Regulation of Self Renewal, and Involvement in Metastasis - Dean Tang Part X: Genomic Signatures of Cancer: Basis for Selective Adjuvant Therapy Chapter 53 Molecular Tecniques to Study Gene Profiles of Cancer - Dominick Sinicropi and Maureen Cronin Chapter 54 Gene Signatures and Profiling in Cancer - Debjani Dutta Chapter 55 Molecular Subgrouping of Breast Cancer Patients - Frederick Baehner Chapter 56 Molecular Subgrouping of Colon Cancer Patients - Wayne Cowens Chapter 57 Validating Gene Expression Signatures in Melanoma – Mohammed Kashani- Sabet Part XI: Promising New Treatments for Solid Tumors Chapter 58 Targeted Therapy for Breast Cancer - Hope Rugo Chapter 59 Signifigance of Circulating Tumor Cells in Breast Cancer and other Solid Tumors – Research and Clinical Applications - Hope Rugo, John Park and Catherine Panabieres Chapter 60 Advances in the Treatment of Colorectal Cancer: Targeting Receptors and Sites of Disease - Alan Venook Chapter 61 Advances in the Treatment of Genitourinary Cancers - Charles Ryan Chapter 62 Advances in the Treatment of Lung Cancer - Sarita Dubey Part XII: Recent Advances in the Treatment of Melanoma Chapter 63 Genomic Characterization of Malignant Melanoma - Boris Bastian Chapter 64 Pegylated Interferons in the Adjuvant Treatment of Melanoma - Dirk Schadendorf Chapter 65 Sorafenib, a Multi-kinase Inhibitor, in Metastatic Melanoma - Axel Hauschild Chapter 66 Breaking Immune Tolerance: a Step Forward in Melanoma Treatment – Antonio Ribas Chapter 67 Cutaneous Metastases: New Treatment Options - Claus Garbe Chapter 68 Neoadjuvant Approaches in Melanoma - John Kirkwood Chapter 69 Chemo-/Biochemotherapy: Old Fashioned or Still a Standard of Care? – Sanjiv Agarwala Part XIII: Special Topics in Oncology Chapter 70 Diagnosis and Intervention of Cancer: Vision of the National Cancer Institute-John E. Niederhuber Chapter 71 The Pathogenesis of Organ-Tissue Specific Metastasis-Isaiah J. Fidler Chapter 72 Lymphatic Mapping and Sentinel Lymphadenectomy: A Personal Journey-Donald Morton Chapter 73 Vascular Endothelial Growth Factor Family, Cancer Biology and Treatment: From Bench to Bedside-Napoleon Ferrara Chapter 74 Proliferation and Cancer Metastasis from the Clinical Point of View-Blake Cady Chapter 75 Future Perspectives- Stanley Leong and Marlys Witte
