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Enzyme Biocatalysis

Principles and Applications

Edited by: Andrés Illanes

Format: Hardback   Published: 8 July 2008, Dordrecht
ISBN-13: 9781402083600   ISBN-10: 1402083602

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Short description for Enzyme Biocatalysis

The book provides a sound basis for enzyme reactor design based on kinetic principles. It also gives an updated vision of the potentials and limitations of enzyme biocatalysis, especially with respect to recent applications in processes of organic synthesis.

 

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Details for Enzyme Biocatalysis

Audience: Research, Professional and scholarly

Other Subjects:

Publisher: SPNL  Imprint: Springer

Pages: 408  Weight: 1.65 kg  Dimensions: 155 x 235 mm


Description for Enzyme Biocatalysis

The book is intended to provide a sound basis for enzyme reactor design based on kinetic principles, and give an updated vision of the potentials and limitations of enzyme biocatalysis, especially with respect to recent applications in processes of organic synthesis. The book is structured in the form of a textbook that goes from basic principles of enzyme structure and function to reactor design for homogeneous systems with soluble enzymes, and heterogeneous systems with insolubilized enzymes. It contains an introductory chapter that gives an updated overview of enzyme technology, a chapter on enzyme production focused on large-scale operations, two chapters devoted to homogeneous and heterogeneous enzyme kinetics and a chapter on enzyme reactor design and operation based on enzyme kinetics principles, mass transfer limitations and enzyme inactivation. The book is complemented with case studies of biocatalytic processes of industrial relevance or potential, written by experts in those fields. Applications of proteases, acylases, lipases, aldolases and dehydrogenases in reactions of organic synthesis, and peroxidases in the degradation of recalcitrant organic compounds, are used as selected examples to illustrate the realities and potentials of enzymes as process catalysts.

Reviews for Enzyme Biocatalysis

Aus den Rezensionen: "… Zielgruppe von ‘Enzyme Biocatalysis‘ sind vor allem PhD-Studierende und Wissenschaftler, die sich in die Biokatalyse einlesen oder vorhaben, sich tiefer mit der Materie zu befassen. Es empfiehlt sich als Anleitung für spezifische anwendungsorientierte Fragestellungen und Nachschlagewerk für kinetische Berechnungen." (in: chemiereport.at, 2008, Issue 8, S. 41)

Features

Presents an updated panorama of enzyme biocatalysis Reviews the current practices of enzyme production with special emphasis on large-scale operations Provides a kinetically based approach to enzyme reactor design and optimization Presents a deep insight into enzyme inactivation mechanisms and its applications for modelling enzyme performance under operating conditions Illustrates the present scenario of enzyme biocatalysis with selected case studies, related mainly to applications in organic synthesis

Table of Contents for Enzyme Biocatalysis

1. Introduction (Andrés Illanes) 2. Enzyme Production (Andrés Illanes) 3. Homogeneous Enzyme Kinetics (Andres Illanes, Claudia Altamirano, Lorena Wilson) 4. Heterogeneous Enzyme Kinetics (Andres Illanes, Roberto Fernández-Lafuente, José Manuel Guisán, Lorena Wilson) 5. Enzyme Reactors (Andrés Illanes, Claudia Altamirano) 6. Study Cases of Enzymatic Processes 6.1. Proteases as catalysts for peptide synthesis (Sonia Barberis, Fanny Guzmán, Josep López-Santín) 6.2. Synthesis of ß-lactam antibiotics with penicillin acylases (Andrés Illanes, Lorena Wilson) 6.3. Chimioselective esterification of wood sterols with lipases (Gregorio Alvaro, Andrés Illanes) 6.4. Oxidoreductases as powerful biocatalysts for green chemistry José Manuel Guisán, Roberto Fernández-Lafuente, Lorena Wilson, César Mateo) 6.5. Use of aldolases for asymmetric synthesis (Josep López-Santín, Gregorio Alvaro, Pere Clapés) 6.6. Application of enzymatic reactors for the degradation of highly and poorly soluble recalcitrant compounds (Juan M. Lema et al.)

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