Drug Resistance in Cancer Cells
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- Research
- Professional and scholarly
Book Description
The inability of cancer drugs to destroy metastatic tumors is the major reason why cancer therapy fails. Even though the process of drug design has become exceedingly sophisticated in recent years, there is not a single drug available that is 100% effective against metastatic cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic/genetic differences in tumors, even those from tissue of origin. Although it is a generally accepted fact that the majority of cancers arise from a single precursor cell, it is naïve to consider that tumor is a collection of genetically identical cells. Genetic instability and accumulation of mutations are important hallmarks of cancer cells. This means that dividing cancer cells are able to acquire genetic and epigenetic changes that will favor their malignant phenotype. In view of this, it is fair to say that the cells in a given tumor may be similar but not identical. Therefore, when treated with a drug, the sensitive cells in a tumor succumb to the toxic effects of the drug, and resistant cells continue to survive and multiply. The tumor, which re-grows from these residual resistant cells, is not sensitive to the original drug.
Other Subjects
Table of Contents
Chapter 1: Drug resistance in cancer cells: a historical perspective (Macus T. Kuo, Houston, TX) or Victor Ling (Toronto, Canada) Chapter 2: Metastasis and drug resistance (Kapil Mehta, Houston, TX) or (Isiah Fidler, Houston, TX) Chapter 3: Apoptosis/autophagy and drug resistance (R.S. Krebel, Ontario, Canada) or (Yasuko Kondo, Houston, TX) Chapter 4: Cytokines and drug resistance (Livio Mallucci, London, UK) Chapter 5: Tissue transglutaminase and drug resistance (KapilMehta, Houston, TX) Chapter 6: Integrin signaling and drug resistance (David Cheresh, San Diego, CA) Chapter 7: Oxidative stress and drug resistance Boldogh, Istvan, UTMB, Galveston, TX) Chapter 8: NF-k B and drug resistance (Bharat B. Aggarwal, Houston, TX) Chapter 9: p53 and chemoresistance (Zahid Siddik, Houston, TX) Chapter 10: Resistance to differentiation therapy (Bulent Ozoplat, Houston, TX) Chapter 11: Assessment of cancer drug resistance by nuclear imaging (Sunil Krishnan, Houston, TX) Chapter 12: Overcoming drug resistance by phytochemicals (Bharat B. Aggarwal. Houston, TX) or (Marion M Chan, Philadelphia, USA)
